and mice exposed to the unique hallucinogen salvinorin A
Journal of Psychoactive Drugs. 35(3): 379382 (2003).
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METHODS: Rats were anesthetized and administered salvinorin A at 1600mcg/kg or vehicle. Recordings were made of galvanic skin response, EKG, temperature, and pulse pressure for 100 minutes. Mice were chronically exposed to vehicle or 400, 800, 1600, 3200, or 6400 mcg/kg of salvinorin A for two weeks. After exposure the animals were sacrificed and brain, heart, kidney, bone marrow, blood and spleen were removed, fixed, sectioned, stained and examined by light microscopy. Results. No effects were seen on cardiac conduction, temperature, or galvanic skin response. A non-significant rise was seen in pulse pressure. Histologic studies of spleen, blood, brain, liver, kidney, and bone marrow did not find any significant histologic changes at any of the doses examined.
CONCLUSIONS: These data suggests that the toxicity of salvinorin A is relatively low, even at doses many times that of what humans are exposed to. However, further studies should be done on blood pressure effects. The psychological impact of this potent hallucinogen should also be investigated.
(I hope to present the full paper at a future date. DS)